Review of coagulation preanalytical variables with update on the effect of direct oral anticoagulants

Abstract There are many preanalytical variables (PAV) that known to affect coagulation testing. The more commonly acknowledged PAV addressed by the clinical laboratory tend start with their influence on blood collection, but realistically starts patient, where has less or control. Patient selection and appropriate timing for collection may be integral assuring proper diagnosis management. Laboratory control assurance ideal phlebotomy practice would mitigate most PAVs related minimize suboptimal sample collection. oversight of transportation, processing storage will assure integrity until testing can facilitated. purpose this document is review common should taken into consideration when ordering, performing interpreting a test result, additional attention effect direct oral anticoagulants (DOACs).